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KMID : 0376219830200030619
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Chonnam Medical Journal
1983 Volume.20 No. 3 p.619 ~ p.624
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Effect of Antibiotics and Specific Phage on Pseudomonas Infection in Mice
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Abstract
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Attempts to increase the susceptibility of mice to pseudomonas infection by treatment with an anticancer drug, cyclophosphamide, and to protect the mice from the pseudomonas infection with antibiotics and pseudomonas phage produced the following results.
Cyclophosphsphamide treatment (300mg/kg) increased the susceptibility of mice to the intraperitoneal pseudomonas infection.
Individual administration of sulbenicillin(80 mg/kg) and amikacin(20 mg/kg) intramuscular protected considerably the mice treated with cyclophosphamide as well as the normal ones. The effect, however, was better in the group treated with sulbenicillin(40 mg/kg) combined with amikacin (l0 mg/kg).
Intraperitoneal administration of pseudomones phage also protected more or less the mice treated with cyclophosphamide and the normal ones.
Antibiotics and pseudomonas phage, however, couldn´t protect the mice challenged with heavy inocula of the organism.
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KEYWORD
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